PIT-1
CAT:
804-HY-103224-02
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PIT-1
- CAS Number: 53501-41-0
- UNSPSC Description: PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo[1].
- Target Antigen: PI3K
- Type: Reference compound
- Related Pathways: PI3K/Akt/mTOR
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/pit-1.html
- Purity: 98.56
- Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(NC(NC1=CC([N+]([O-])=O)=CC(Cl)=C1O)=S)C2=CC=CC=C2
- Molecular Weight: 351.76
- References & Citations: [1]Miao B, et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported