DAB2 rabbit pAb

• Background:

  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Description:

  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

• UniProt:

  P98082

• Swiss Prot:

  P98082

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from human DAB2 AA range: 683-733

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000

• Molecular Weight:

  85kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  85kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, clathrin-coated pit. Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm.

• Other Product Names:

  Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)

• Gene ID (Human):

  1601