Sapropterin-d3
CAT:
804-HY-144856S1
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Sapropterin-d3
- CAS Number: 2747956-15-4
- UNSPSC Description: Sapropterin-d3 ((6R)-BH4-d3) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU)[1][2].
- Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds
- Type: Isotope-Labeled Compounds
- Related Pathways: Metabolic Enzyme/Protease;Others
- Field of Research: Metabolic Disease
- Smiles: O=C1N=C(N)NC2=C1NC([C@@H](O)[C@@H](O)C([2H])([2H])[2H])CN2
- Molecular Weight: 244.27
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021 Jul;18(3):1862-1879.|[3]Sanford M, et al. Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia. Drugs. 2009;69(4):461-76.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported