Sapropterin

• UNSPSC Description:

  Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU)[1].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/Sapropterin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(NC(N)=N1)NC[C@](N2)([H])[C@@H](O)[C@@H](O)C

• Molecular Weight:

  241.25

• References & Citations:

  [1]Sanford M, et al. Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia. Drugs. 2009;69(4):461-76. |[2]Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021 Jul;18(3):1862-1879.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  62989-33-7