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Sapropterin

CAT: 0804-HY-A0124Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0124Size:1 Each
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Description
Sapropterin ((6R) -BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) [1].
CAS Number
62989-33-7
Product Name Alternative
(6R) -BH4; (6R) -Tetrahydro-L-biopterin
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Sapropterin.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NC(N)=N1)NC[C@](N2)([H])[C@@H](O)[C@@H](O)C
Molecular Formula
C9H15N5O3
Molecular Weight
241.25
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Sanford M, et al. Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia. Drugs. 2009;69 (4) :461-76. |[2]Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021 Jul;18 (3) :1862-1879.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Citation 01
Immunol Invest. 2025 Nov;54 (8) :1542-1560.|Mol Cell. 2020 Jan 2;77 (1) :95-107.e5.

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