Sapropterin

• Description :

  Sapropterin ((6R) -BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) [1].

• Product Name Alternative :

  (6R) -BH4; (6R) -Tetrahydro-L-biopterin

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/Sapropterin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C2=C(NC(N)=N1)NC[C@](N2)([H])[C@@H](O)[C@@H](O)C

• Molecular Formula :

  C9H15N5O3

• Molecular Weight :

  241.25

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

• References & Citations :

  [1]Sanford M, et al. Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia. Drugs. 2009;69 (4) :461-76. |[2]Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021 Jul;18 (3) :1862-1879.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  Human Endogenous Metabolite

• Citation 01 :

  Immunol Invest. 2025 Nov;54 (8) :1542-1560.|Mol Cell. 2020 Jan 2;77 (1) :95-107.e5.

• CAS Number :

  [62989-33-7]