L82-G17

L82-G17

• CAS Number: 92285-87-5
• UNSPSC Description: L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/l82-g17.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C1NN=CC(N/N=C/C2=CC(O)=CC=C2)=C1Cl
• Molecular Weight: 264.67
• References & Citations: [1]Timothy R L Howes, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported