Anti-Catenin, alpha-1 (CTNNA1) (1G5), CF594 conjugate
CAT:
37-BNC941364-500
Size:
500 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Catenin, alpha-1 (CTNNA1) (1G5), CF594 conjugate
- Description: Alpha-E-catenin (also known as Alpha-1 catenin) is part of the catenin family, a large family of Ca2 -dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-E-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-E-catenin forms a heterodimer with beta-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-E-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: Alpha-E-catenin; Alpha-1 catenin; Cadherin-associated protein; Catenin alpha-1; CTNNA1
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: CTNNA1
- Gene ID: 1495
- NCBI Gene ID: 445981
- UniProt: P35221
- Cellular Locus: Plasma membrane
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Human alpha catenin fusion protein
- Target Antigen: Alpha-1 catenin | Alpha-E-catenin
- Clonality: Monoclonal
- Isotype: IgG1
- Clone: 1G5
- Conjugation: CF594
- Disease: Tumor
- Source: Animal
- Applications: WB (verified)
- Validated Applications: WB
- Field of Research: Cancer
- Positive Control: HeLa, A431 or MCF-7 Cells.
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: 102 kDa
- Additionnal Information: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 1-2 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL|Western blotting 0.5-1 ug/mL|Optimal dilution for a specific application should be determined by user
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years