Catenin, alpha-1 (CTNNA1)

• Gene Name:

  [CTNNA1]

• NCBI Gene ID:

  1495

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 °C.
  Antibody without azide - store at -20 to -80 °C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-catenin forms a heterodimer with beta-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.

• Other Gene Names:

  [CTNNA1; CTNNA1; MDPT2; CAP102]

• Short Name:

  [Catenin, alpha-1 (CTNNA1)]

• Other Product Names:

  [catenin alpha-1 isoform 2; Catenin alpha-1; catenin alpha-1; catenin alpha 1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13]

• NCBI GI Number:

  594140506

• NCBI Accession Number:

  NP_001277236.1

• NCBI GB Accession Number:

  NM_001290307.2

• Uniprot Accession Number:

  P35221