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γ-Kainylglutamic acid

CAT: 0804-HY-118758Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118758Size:1 Each
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Description
γ-Kainylglutamic acid (γ-Kainic acid-glutamic acid), a dipeptide derived from kainic and L-Glutamic acids, is a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties. γ-Kainylglutamic acid inhibits the stimulation of Na+ fluxes induced in brain slices by the neuroexcitant N-methyl-D-aspartic acid. γ-Kainylglutamic acid is also effective in protecting mice from picrotoxin-induced convulsions with an EC50 value of 0.17 μmol[1].
CAS Number
98394-38-8
Product Name Alternative
γ-Kainic acid-glutamic acid
UNSPSC
12352211
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/γ-kainylglutamic-acid.html
Smiles
OC(CC[C@@H](C(O)=O)NC(C[C@H]1[C@H](CN[C@@H]1C(O)=O)C(C)=C)=O)=O
Molecular Formula
C15H22N2O7
Molecular Weight
342.34
References & Citations
[1]Goldberg O, et al. A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties. J Med Chem. 1985 Dec;28 (12) :1957-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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