2,4-Dihydroxybenzoic acid

• Description :

  2,4-Dihydroxybenzoic acid is a degradation product of acid cherry anthocyanins during in vitro cell culture and an analogue of coenzyme Q precursor molecules. 2,4-Dihydroxybenzoic acid can improve the related symptoms of kidney diseases caused by ADCK4/Coq6 deficiency[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H317

• Target :

  Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/2,4-Dihydroxybenzoic_acid.html

• Concentration :

  10mM

• Purity :

  99.95

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1=CC=C(O)C=C1O

• Molecular Formula :

  C7H6O4

• Molecular Weight :

  154.12

• Precautions :

  H317

• References & Citations :

  [1]Seeram NP, et al. Degradation products of cyanidin glycosides from tart cherries and their bioactivities. J Agric Food Chem. 2001 Oct;49 (10) :4924-9.|[2]Widmeier E, et al. Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice. J Am Soc Nephrol. 2019 Mar;30 (3) :393-405.|[3]Widmeier E, et al. ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. J Am Soc Nephrol. 2020 Jun;31 (6) :1191-1211.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [89-86-1]