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3,5-Dihydroxybenzoic acid

CAT: 0804-HY-W015560-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W015560-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses. 3,5-Dihydroxybenzoic acid is the agonist for hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) that inhibits lipolysis in adipocytes. 3,5-Dihydroxybenzoic acid is the competitive inhibitor for tyrosine phenol-lyase (TPL), exhibits an affinity of Ki=25.7 μM. 3,5-Dihydroxybenzoic acid is orally active[1][2].
CAS Number
99-10-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR) ; Tyrosinase
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/3,5-Dihydroxybenzoic_acid.html
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 60 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC(O)=CC(O)=C1
Molecular Formula
C7H6O4
Molecular Weight
154.12
Precautions
H315, H319
References & Citations
[1]Liu C, et al., 3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther. 2012 Jun;341 (3) :794-801.|[2]Kobayashi T, et al., 3,5-Dihydroxybenzoic Acid as a Potent Inhibitor of Tyrosine Phenol-Lyase Decreases Fecal Phenol Levels in Mice. J Med Chem. 2025 Apr 2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HCAR1

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