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Lensiprazine

CAT: 0804-HY-14793-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14793-01Size:1 mg
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Description
Lensiprazine is a potent dopamine D2 receptor (D2R) antagonist that acts as a serotonin reuptake inhibitor. Lensiprazine can be used to study bipolar disorder and schizophrenia[1][2][3].
CAS Number
327026-93-7
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lensiprazine.html
Smiles
C[C@H]1OC2=C(N3CCN(CC3)CCCC(C4=C5)=CNC4=CC=C5F)C=CC=C2NC1=O
Molecular Formula
C24H27FN4O2
Molecular Weight
422.50
References & Citations
[1]Bollu R, et al. Potential anti-proliferative agents from 1, 4-benzoxazinone-quinazolin-4 (3H) -one templates[J]. Bioorganic & Medicinal Chemistry Letters, 2017, 27 (24) : 5481-5484.|[2]Lange J H M, et al. Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs[J]. Journal of medicinal chemistry, 2007, 50 (21) : 5103-5108.|[3]Rauly-Lestienne I, et al. Differential profile of typical, atypical and third generation antipsychotics at human 5-HT 7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties[J]. Naunyn-Schmiedeberg's archives of pharmacology, 2007, 376: 93-105.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Lensiprazine

Lensiprazine is a small molecule drug. Lensiprazine has a monoisotopic molecular weight of 422.21 Da.

CAS Number327026-93-7
PubChem CID9954003
IUPAC Name(2R)-8-[4-[3-(5-fluoro-1H-indol-3-yl)propyl]piperazin-1-yl]-2-methyl-4H-1,4-benzoxazin-3-one
Molecular FormulaC24H27FN4O2
Molecular Weight422.5
XLogP3.8
Topological Polar Surface Area60.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity629
SMILES
C[C@@H]1C(=O)NC2=C(O1)C(=CC=C2)N3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)F
InChI
InChI=1S/C24H27FN4O2/c1-16-24(30)27-21-5-2-6-22(23(21)31-16)29-12-10-28(11-13-29)9-3-4-17-15-26-20-8-7-18(25)14-19(17)20/h2,5-8,14-16,26H,3-4,9-13H2,1H3,(H,27,30)/t16-/m1/s1
InChIKey
SDAMYSWGWHXMRT-MRXNPFEDSA-N
Chemical Structure
2D Structure
2D structure of Lensiprazine
CAS: 327026-93-7
CID: 9954003
Formula: C24H27FN4O2
MW: 422.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight422.5
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass422.21180428
Monoisotopic Mass422.21180428
Topological Polar Surface Area60.6 Ų
Heavy Atom Count31
Formal Charge0
Complexity629
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5782201Lensiprazine

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