(S,R,S)-AHPC-C4-NH2 (hydrochloride)

• CAS Number:

  2245697-83-8

• UNSPSC Description:

  (S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Protac_linker_5.html

• Purity:

  99.29

• Solubility:

  DMSO : ≥ 109.6 mg/mL|H2O : ≥ 50 mg/mL

• Smiles:

  O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)CCCCN.[H]Cl

• Molecular Weight:

  566.16

• References & Citations:

  [1]Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported