5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

• CAS Number:

  23669-79-6

• UNSPSC Description:

  5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks[1][2].

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/5-o-4-4-dimethoxytrityl-2-deoxyuridine.html

• Purity:

  98.20

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](O)C[C@@H](O3)N4C=CC(NC4=O)=O)C5=CC=CC=C5)C=C1

• Molecular Weight:

  530.57

• References & Citations:

  [1]Hidalgo-Zarco F, et, al. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major. Protein Sci. 2001 Jul;10(7):1426-33.|[2]Hovinen J, et, al. Versatile strategy for oligonucleotide derivatization. Introduction of lanthanide(III) chelates to oligonucleotides. Org Lett. 2001 Aug 9;3(16):2473-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported