HighYield T7 mRNA Modification Testkit (ARCA)

• Description:

  HighYield T7 mRNA Modification Testkit (ARCA) is designed to produce large amounts of differentially uridine-, cytidine- or adenosine-modified (m)RNA via in vitro transcription with T7 RNA polymerase. Included Cap analog ARCA allows additional co-transcriptional introduction of a Cap 0 moiety. The resulting 5'-capped (m)RNA can subsequently be used for microinjection, transfection or in vitro translation experiments. Epigenetic internal mRNA modifications e.g. (pseudo)uridine methylation or thiolation as well as 5'-capping have been shown to increase translation efficiency and to reduce immunogenicity [1]-[10] however, the optimal combination needs to be individually termined for each mRNA target.

• Product Name Alternative:

  Synthesis of differentially uridine-, cytidine- or adenosine-modified (m) RNA with Cap 0 structure

• Synonyms:

  Synthesis of differentially uridine-, cytidine- or adenosine-modified (m)RNA with Cap 0 structure

• UNSPSC:

  41100000

• UNSPSC Description:

  Laboratory and scientific equipment

• HS Code:

  38220000

• eClass Number:

  32160405

• eClass Product Group:

  Biochemikalie (Labor, Sonstige)

• Autoclavability:

  false

• Shipping Conditions:

  Shipped on gel packs

• Storage Conditions:

  Avoid freeze/thaw cycles

• Storage Temperature:

  Store at -20 °C

• Shelf Life:

  12 months after date of delivery