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(S) -Rivastigmine-d4

CAT: 0804-HY-W654336Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W654336Size:1 mg
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Description
(S) -Rivastigmine-d4 is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB) . Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2][3].
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Isotope-Labeled Compounds
Type
Reference compound
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
CCN(C(OC1=CC([C@@H](N(C([2H])([H])[2H])C([2H])([H])[2H])C)=CC=C1)=O)C
Molecular Formula
C14H18D4N2O2
Molecular Weight
254.36
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Qian-Sheng Yu, et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem. 2002 Aug 15;45 (17) :3684-91.|[3]Helena Shifrin, et al. Rivastigmine alleviates experimentally induced colitis in mice and rats by acting at central and peripheral sites to modulate immune responses. PLoS One. 2013;8 (2) :e57668.|[4]Han HJ, Lee JJ, Park SA et al. Efficacy and safety of switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch in patients with probable Alzheimer's disease. J Clin Neurol. 2011 Sep;7 (3) :137-42.|[5]Raafat A Abdel-Aal, et al. Rivastigmine reverses aluminum-induced behavioral changes in rats. Eur J Pharmacol. 2011 Jun 1;659 (2-3) :169-76.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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