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Rivastigmine

CAT: 0804-HY-17368-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17368-01Size:50 mg
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Description
Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB) . Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].
CAS Number
123441-03-2
Product Name Alternative
ENA 713 (free base) ; SDZ-ENA 713 (free base)
UNSPSC
12352005
Hazard Statement
H300, H411
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Rivastigmine.html
Purity
99.93
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(N(C)CC)OC1=CC=CC([C@H](C)N(C)C)=C1
Molecular Formula
C14H22N2O2
Molecular Weight
250.34
Precautions
H300, H411
References & Citations
[1]Qian-Sheng Yu, et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem. 2002 Aug 15;45 (17) :3684-91.|[2]Han HJ, Lee JJ, Park SA et al. Efficacy and safety of switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch in patients with probable Alzheimer's disease. J Clin Neurol. 2011 Sep;7 (3) :137-42.|[3]Helena Shifrin, et al. Rivastigmine alleviates experimentally induced colitis in mice and rats by acting at central and peripheral sites to modulate immune responses. PLoS One. 2013;8 (2) :e57668.|[4]Raafat A Abdel-Aal, et al. Rivastigmine reverses aluminum-induced behavioral changes in rats. Eur J Pharmacol. 2011 Jun 1;659 (2-3) :169-76.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AChE; BChE

Alternative Products

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A8515-10Rivastigmine Tartrate
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