Anti-Zyxin

• Description :

  Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

• CAS Number :

  9007-83-4

• Reactivity :

  Human

• Immunogen :

  Synthetic peptide conjugated to KLH

• Clonality :

  Polyclonal

• Type :

  Antibodies-Polyclonal

• Applications :

  WB,ELISA,ICC/IF

• Concentration :

  100ug/100ul

• Purity :

  Protein A purified

• Buffer :

  PBS, pH 7.4 with 0.02% Sodium Azide

• Shipping Conditions :

  Ice Pack

• Storage Conditions :

  This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Fragment :

  Rabbit IgG

• Specificity :

  Not tested with other proteins

• Applications Notes :

  Recommended dilutions Peptide ELISA: 1:32,000 IF: 1/50. WB: 1/500 - 1/1000. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user