Anti-MTH1

• Description:

  Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide conjugated to KLH

• Clonality:

  Polyclonal

• Type:

  Antibodies-Polyclonal

• Applications:

  WB,ELISA

• Purity:

  Serum

• Buffer:

  PBS, pH 7.4 with 0.02% Sodium Azide

• Shipping Conditions:

  Ice Pack

• Storage Conditions:

  This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Fragment:

  Rabbit IgG

• Specificity:

  MTH1 antibody detects endogenous levels of MTH1 protein. Not tested with other proteins

• Applications Notes:

  Recommended dilutions Peptide ELISA: 1:40,000 WB: 1/200 - 1/1000 Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user

• CAS Number:

  9007-83-4