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Anti-Bcl6

CAT: 0171-Y300109Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0171-Y300109Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl6 is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. It has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. Bcl6 can also interact with a variety of POZ-containing proteins that function as transcription corepressors. Its gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Other diseases associated with Bcl6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma.
CAS Number
9007-83-4
Reactivity
Human
Immunogen
Recombinant human Bcl6 protein
Clonality
Monoclonal
Type
Antibodies-Monoclonal
Applications
WB,IHC,IP,Other
Concentration
100µg/100µl
Purity
The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Buffer
PBS, pH 7.4 with 0.05% sodium azide
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG2b
Specificity
Human Bcl6
Applications Notes
WB: 1:2000~1:5000 IHC: 1:200~1:500 IP: 1:1000~1:2000 Optimal dilutions should be calculated by the end user based on their specific application.

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