Anti-APP (Ab-668)

• Description:

  This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Reactivity:

  Human,Mouse,Rat

• Immunogen:

  The antiserum was produced against synthesized non-phosphopeptide derived from human APP around the phosphorylation site of threonine 668 ( A-V-TP-P-E ).

• Clonality:

  Polyclonal

• Type:

  Antibodies-Polyclonal

• Applications:

  WB

• Concentration:

  1ug/ul

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Buffer:

  phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Shipping Conditions:

  Ice Pack

• Storage Conditions:

  This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

• Specificity:

  APP (Ab-668) antibody detects endogenous levels of total APP protein.

• Applications Notes:

  WB: 1:500~1:1000

• CAS Number:

  9007-83-4