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APP (phospho 668) Antibody

CAT: 0223-79-467Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-467Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene.
NCBI Gene ID
351
Swiss Prot
P05067
Accession Number
NP_000475.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
APP (Phospho-668) antibody was raised against a peptide sequence around phosphorylation site of threonine 668 (A-V-T (p) -P-E) derived from Human APP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific, Neuroscience
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
100 - 140 kDa
Specificity
This antibody detects endogenous level of APP only when phosphorylated at threonine 668.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
APP
NCBI Official Name
Amyloid beta (A4) precursor protein
NCBI Organism
Homo sapiens
Background Reference 01
Hung, A. Y. and Selkoe, D. J. (1994) EMBO J. 13, 534-542. Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427. Iijima, K. I. et al. (2000) J. Neurochem. 75, 1085-1091
Other Product Names
AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, Nrage, AAA
Tested Applications
WB
Protein ID
4502167
Physical Properties
Liquid

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