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Anti-Androgen Receptor

CAT: 0171-Y058080Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0171-Y058080Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
CAS Number
9007-83-4
Reactivity
Human,Mouse
Immunogen
Synthetic peptide conjugated to KLH
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,ELISA
Concentration
100ug/100ul
Purity
Purified
Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
Rabbit IgG
Specificity
Androgen Receptor antibody detects endogenous levels of Androgen Receptor protein. Not tested with other proteins
Applications Notes
Recommended dilutions Peptide ELISA: 1:40,000 WB: 1/200 - 1/1000 Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user

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