Anti-Glucagon Receptor

• Description:

  Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior. Both glucagon and GLP-1 function through their specific binding to the glucagon receptor or GLP-1R, respectively. The glucagon receptor shows expression in liver, kidney and adipose tissue. The GLP-1R expression primarily localizes to areas of the hypothalamus involved in feeding behavior. Both receptors and their ligands serve as potential targets for the therapeutic treatment of diabetes.

• Reactivity:

  Human,Mouse,Rat

• Immunogen:

  Recombinant human Glucagon Receptor protein

• Clonality:

  Polyclonal

• Type:

  Antibodies-Polyclonal

• Applications:

  WB,ELISA,IP

• Concentration:

  100ug/100ul

• Purity:

  Affinity purified

• Buffer:

  PBS, pH 7.4 with 0.02% sodium azide.

• Shipping Conditions:

  Ice Pack

• Storage Conditions:

  Store at -20°C/1 year

• Fragment:

  IgG

• Specificity:

  Epitope mapping within an extracellular domain of the human Glucagon Receptor

• Applications Notes:

  Western Blotting (starting dilution 1:200, dilution range 1:100-1:1000), immunoprecipitation [1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)], immunofluorescence (starting dilution 1:50, dilution range 1:50-1:500) and solid phase ELISA (starting dilution 1:30, dilution range 1:30-1:3000).

• CAS Number:

  9007-83-4