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Anti-Raf1 (Phospho-Ser338)

CAT: 0171-Y011204Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0171-Y011204Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
CAS Number
9007-83-4
Reactivity
Human,Mouse
Immunogen
The antibody was produced against synthesized phosphopeptide derived from human Raf1 around the phosphorylation site of serine 338 (R-D-SP-S-Y).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG
Specificity
Raf1 (phospho-Ser338) antibody detects endogenous levels of Raf1 only when phosphorylated at serine 338.
Applications Notes
WB: 1:500~1:1000

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