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Anti-Raf1 (Ab-259)

CAT: 0171-Y021006Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0171-Y021006Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
CAS Number
9007-83-4
Reactivity
Human,Mouse,Rat
Immunogen
This antiserum was produced against synthesized non-phosphopeptide derived from human Raf-1 around the phosphorylation site of serine 259 (S-T-SP-T-P).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IHC
Concentration
1ug/ul
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Specificity
Raf-1 (Ab-259) antibody detects endogenous levels of total Raf-1 protein.
Applications Notes
WB: 1:500~1:1000 IHC: 1:50~1:100

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