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Anti-CDK6 (Ab-13)

CAT: 0171-Y021542Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0171-Y021542Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
CAS Number
9007-83-4
Reactivity
Human,Mouse
Immunogen
The antibody was produced against synthesized non-phosphopeptide derived from human CDK6 around the phosphorylation site of tyrosine 13 (Q-Q-YP-E-C).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
IHC,IP
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
Rabbit IgG in phosphate buffered saline (without Mg<sup>2</sup>+ and Ca<sup>2</sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG
Specificity
CDK6 (Ab-13) Antibody detects endogenous levels of total CDK6 protein.
Applications Notes
IHC: 1:50~1:100 IF:1:100~1:200

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