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Anti-ATM (Ab-1981)

CAT: 0171-Y021147Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0171-Y021147Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
CAS Number
9007-83-4
Reactivity
Human,Mouse
Immunogen
The antibody was produced against synthesized non-phosphopeptide derived from human ATM around the phosphorylation site of serine 1981 (E-G-SP-Q-S).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IP
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
Rabbit IgG in phosphate buffered saline (without Mg<sup>2</sup>+ and Ca<sup>2</sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG
Specificity
ATM (Ab-1981) Antibody detects endogenous levels of total ATM protein.
Applications Notes

WB: 1:500~1:1000 IF:1:100~1:200

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