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ATM (Ab 1981) Antibody

CAT: 0223-79-558Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-558Size:0.1 mg
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Background
ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
472
Swiss Prot
Q13315
Accession Number
NP_000042.3
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
ATM (Ab-1981) antibody was raised against a peptide sequence around aa.1979~1983 (E-G-S-Q-S) derived from Human ATM.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
350 kDa
Specificity
This antibody detects endogenous level of total ATM protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Symbol
ATM
NCBI Official Name
Ataxia telangiectasia mutated
NCBI Organism
Homo sapiens
Background Reference 01
Gupta A. et al. (2005) Mol Cell Biol. 25 (12) : 5292-5305. Bernstein JL. et al. (2002) Breast Cancer Res. 4 (6) : 249-252. Silverman J. et al. (2004) Genes Dev. 18 (17) : 2108-2119. Nakada D. et al. (2003) Nucleic Acids Res. 31 (6) : 1715-1724.
Other Product Names
AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, C1orf215, LAP18, OP18, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, kinase ATM
Tested Applications
WB, IF
Protein ID
71902540
Physical Properties
Liquid

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