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Recombinant Rat IL2

CAT: 0171-Z300197Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0171-Z300197Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rat IL2, also known as T-cell growth factor, is a secreted immunoregulatory cytokine produced by T-cells due to antigenic or mitogenic stimulation. IL2 binds to the IL2 receptor, which is found in T and B cells and natural killer cells, and is composed of three distinct components: the cytokine specific α-chain, and the β– and γc-subunits. Its receptor complex IL2 induces the proliferation of T cells, generation of cytotoxic T lymphocytes (CTLs), proliferation and synthesis of immunoglobulin by B cells, and the survival of natural killer cells. Its heterotrimeric receptor complex is also shared by Interleukin 4 (IL4) and Interleukin 7 (IL7) by its gamma chain, and receptor signalling is essential for its expression and differentiation of regulatory T cells in the immune response.
CAS Number
9000-83-3
Gene Name
IL2
Gene Aliases
T-cell growth factor
Gene ID
116562
Accession Number
P17108
Organism
Rat
Source
E. coli
Concentration
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity
>95% as determined by SDS-PAGE
Function
The ED50 was 0.04-0.2 ng/mL as determined by a cell proliferation assay
Molecular Weight
15.6
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 µm filtered solution in ammonium acetate and glycerol (with BSA as a carrier protein)

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