Recombinant Rat IL2

• Description :

  Rat IL2, also known as T-cell growth factor, is a secreted immunoregulatory cytokine produced by T-cells due to antigenic or mitogenic stimulation. IL2 binds to the IL2 receptor, which is found in T and B cells and natural killer cells, and is composed of three distinct components: the cytokine specific α-chain, and the β– and γc-subunits. Its receptor complex IL2 induces the proliferation of T cells, generation of cytotoxic T lymphocytes (CTLs), proliferation and synthesis of immunoglobulin by B cells, and the survival of natural killer cells. Its heterotrimeric receptor complex is also shared by Interleukin 4 (IL4) and Interleukin 7 (IL7) by its gamma chain, and receptor signalling is essential for its expression and differentiation of regulatory T cells in the immune response.

• CAS Number :

  9000-83-3

• Gene Name :

  IL2

• Gene Aliases :

  T-cell growth factor

• Gene ID :

  116562

• Accession Number :

  P17108

• Organism :

  Rat

• Source :

  E. coli

• Concentration :

  <1.0 EU/μg of recombinant protein as determined by the LAL method

• Purity :

  >95% as determined by SDS-PAGE

• Function :

  The ED50 was 0.04-0.2 ng/mL as determined by a cell proliferation assay

• Molecular Weight :

  15.6

• Shipping Conditions :

  Ambient Temperature

• Storage Conditions :

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance :

  Lyophilized Powder

• Formulation :

  Lyophilized from a 0.2 µm filtered solution in ammonium acetate and glycerol (with BSA as a carrier protein)