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Recombinant Rat IL1B

CAT: 0171-Z300077Size: 100 µgDry Ice: NoHazardous: No
CAT#:0171-Z300077Size:100 µg
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Description
Monocytes are the main source of secreted IL-1. They express predominantly IL-1-beta while human keratinocytes express large amounts of IL-1-alpha. Murine macrophages display a transition from IL-1-beta to IL-1-alpha production during maturation of monocytes into inflammatory macrophages. There are two functionally almost equivalent forms of IL-1, IL-1-alpha and IL-1-beta that are encoded by two different genes. IL-1-beta is the predominant form in humans while it is IL-1-alpha in mice. Both forms of IL-1 bind to the same receptor and therefore also show similar if not identical biological activities. The IL-1-beta but not the IL-1-alpha precursor must be processed before it can bind to the receptor. Both forms of IL-1 bind to the same receptor and therefore also show similar if not identical biological activities. The receptor isolated from T cells is expressed predominantly on T cells and cells of mesenchymal origin. It binds both types of IL-1 with equal affinity. This type is called also Type 1 receptor. It has been designated CD121a. The Type 2 receptor has been designated CD121b. It is isolated from B cells, granulocytes, and macrophages. It is expressed predominantly on B cells and cells of the myelomonocytic lineage and is encoded by a separate gene.
CAS Number
9000-83-3
Gene Name
IL1B
Gene Aliases
IL-1b
Recombinant Rat Interleukin-1 Beta (IL1B)
Gene ID
24494
Accession Number
Q63264
Organism
Rat
Source
E. coli
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED(50) was determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 2.0 pg/mL, corresponding to a specific activity of ≥ 5.0 x 10^8 units/mg.
Molecular Weight
17
Shipping Conditions
Ambient Temperature
Storage Conditions
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favourable performance, avoid repeated handling and multiple freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Rat IL-1 beta was lyophilized from a 0.2 μm filtered solution in PBS, pH 7.

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