Recombinant Mouse IL25

• Description:

  IL-25 (also known as IL- 17E), a member of the IL-17 family, has been implicated in Th2 cell-mediated immunity. Recently, IL-25 has been identified as one of the initiators of the Th2 response (10, 11) and has also been shown to be expressed by mast cells. The transgenic overexpression of IL-25 by lung epithelial cells results in mucus hyperproduction and airway infiltration of macrophages and eosinophils; conversely, IL-25 blockade reduced airway inflammation and Th2 cytokine production in an allergen-induced asthma model.

• Gene Name:

  IL25

• Gene Aliases:

  UPF0556 protein, IL-25, Stromal cell-derived growth factor SF20, D17Wsu104e, Il25
  Recombinant Mouse Interleukin-25 (IL25)

• Gene ID:

  140806

• Accession Number:

  Q9CPT4

• Organism:

  Mouse

• Source:

  E. coli

• Concentration:

  <1.0 EU/μg of recombinant protein as determined by the LAL method

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

• Function:

  The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.5ng/mL.

• Molecular Weight:

  16

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Lyophilized from 0.2μm filtered solution in Tris and NaCl

• CAS Number:

  9000-83-3