Recombinant Mouse IL25

Recombinant Mouse IL25

• Description: IL-25 (also known as IL- 17E), a member of the IL-17 family, has been implicated in Th2 cell-mediated immunity. Recently, IL-25 has been identified as one of the initiators of the Th2 response (10, 11) and has also been shown to be expressed by mast cells. The transgenic overexpression of IL-25 by lung epithelial cells results in mucus hyperproduction and airway infiltration of macrophages and eosinophils; conversely, IL-25 blockade reduced airway inflammation and Th2 cytokine production in an allergen-induced asthma model.
• CAS Number: 9000-83-3
• Gene Name: IL25
• Gene Aliases: UPF0556 protein, IL-25, Stromal cell-derived growth factor SF20, D17Wsu104e, Il25
  Recombinant Mouse Interleukin-25 (IL25)
• Gene ID: 140806
• Accession Number: Q9CPT4
• Organism: Mouse
• Source: E. coli
• Concentration: <1.0 EU/μg of recombinant protein as determined by the LAL method
• Purity: >95% as determined by SDS-PAGE
• Solubility: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Function: The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be &lt;0.5ng/mL.
• Molecular Weight: 16
• Shipping Conditions: Ambient Temperature
• Storage Conditions: Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
• Appearance: Lyophilized Powder
• Formulation: Lyophilized from 0.2μm filtered solution in Tris and NaCl