Recombinant Mouse IL17

CAT: 0171-Z200435Size: 25 µgDry Ice: NoHazardous: No
CAT#:0171-Z200435Size:25 µg
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Description
Interleukin-17 (IL-17 or IL-17A) is the founder member of the IL-17 cytokine family, which shares 50% homology with IL-17F. IL-17 cytokines are produced by T helper (TH)17 cells, gamma delta T cells, and other immune cells. IL-17A and IL-17F form homodimers and heterodimers as functional ligands. IL-17 cytokines bind to two receptors, IL-17RA and IL-17RC. IL-17RC forms a receptor heterodimer with IL-17RA. The receptor heterodimer is preferred by IL-17 ligands, thus, either IL-17RA knockout (KO) or IL-17RC KO completely abolishes IL-17 signaling. IL-17A and IL-17F are key proinflammatory cytokines involved in many inflammatory and autoimmune diseases.
CAS Number
9000-83-3
Gene Name
IL17
Gene Aliases
Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, Ctla8, Il17
Recombinant Mouse Interleukin-17 (IL17)
Gene ID
16171
Accession Number
Q62386
Organism
Mouse
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Function
The ED(50) was determined by the dose-dependent proliferation of immortalized human gingival keratinocytes (Gie-No3B11) and was found to be <0.5ng/mL.
Molecular Weight
16
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS

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