Recombinant Human MANF

• Description:

  MANF is a neurotrophic factor found mainly in central nervous tissues where it may remain localized to the endoplasmic reticulum and in the Golgi apparatus, or secreted. It has been shown that MANF plays an important role in protecting cells against tunicamycin and thapsigargin-induced cell death. Without MANF, cells become increasingly vulnerable to the aforementioned drugs. Also, MANF is structurally homologous to CDNF.

• Gene Name:

  MANF

• Gene Aliases:

  Arginine-rich protein, Protein ARMET, ARP
  Recombinant Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)

• Gene ID:

  7873

• Accession Number:

  P55145

• Organism:

  Human

• Source:

  E. coli

• Concentration:

  < 1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  Reconstitute at 200 μg/mL in PBS

• Function:

  N.A.

• Molecular Weight:

  18.4

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Lyophilized from a 0.2 μm filtered solution in PBS

• CAS Number:

  9000-83-3