Recombinant Human MANF

• Description:

  MANF is a neurotrophic factor found mainly in central nervous tissues where it may remain localized to the endoplasmic reticulum/Golgi apparatus, or secreted. It has been shown that MANF plays an important role in protecting cells against tunicamycin and thapsigargin -induced cell death. Without MANF, cells become increasingly vulnerable to the aforementioned drugs. Also, MANF is structurally homologous to CDNF.

• Gene Name:

  MANF

• Gene Aliases:

  Arginine-rich protein, Protein ARMET, ARP
  Recombinant Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)

• Gene ID:

  7873

• Accession Number:

  P55145

• Organism:

  Human

• Source:

  E. coli

• Concentration:

  < 1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  Reconstitute at 200 μg/mL in PBS

• Function:

  N.A.

• Molecular Weight:

  18.4

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Lyophilized from a 0.2 μm filtered solution in PBS

• CAS Number:

  9000-83-3