Recombinant Human MANF

• Description :

  MANF is a neurotrophic factor found mainly in central nervous tissues where it may remain localized to the endoplasmic reticulum/Golgi apparatus, or secreted. It has been shown that MANF plays an important role in protecting cells against tunicamycin and thapsigargin -induced cell death. Without MANF, cells become increasingly vulnerable to the aforementioned drugs. Also, MANF is structurally homologous to CDNF.

• Gene Name :

  MANF

• Gene Aliases :

  Arginine-rich protein, Protein ARMET, ARP
  Recombinant Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)

• Gene ID :

  7873

• Accession Number :

  P55145

• Organism :

  Human

• Source :

  E. coli

• Concentration :

  <1.0 EU/μg of recombinant protein as determined by the LAL method

• Purity :

  >95% as determined by SDS-PAGE

• Solubility :

  Reconstitute at 200 μg/mL in PBS

• Function :

  The ED50 was found to be <0.5ng/ml using dose dependent proliferation of human pancreatic cells.

• Molecular Weight :

  18.4

• Shipping Conditions :

  Ambient Temperature

• Storage Conditions :

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance :

  Lyophilized Powder

• Formulation :

  Lyophilized from a 0.2 μm filtered solution in PBS

• CAS Number :

  9000-83-3