Recombinant Human MANF

CAT: 0171-Z102065Size: 40 µgDry Ice: NoHazardous: No
CAT#:0171-Z102065Size:40 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MANF is a neurotrophic factor found mainly in central nervous tissues where it may remain localized to the endoplasmic reticulum/Golgi apparatus, or secreted. It has been shown that MANF plays an important role in protecting cells against tunicamycin and thapsigargin -induced cell death. Without MANF, cells become increasingly vulnerable to the aforementioned drugs. Also, MANF is structurally homologous to CDNF.
CAS Number
9000-83-3
Gene Name
MANF
Gene Aliases
Arginine-rich protein, Protein ARMET, ARP
Recombinant Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)
Gene ID
7873
Accession Number
P55145
Organism
Human
Source
E. coli
Concentration
<1.0 EU/μg of recombinant protein as determined by the LAL method
Purity
>95% as determined by SDS-PAGE
Solubility
Reconstitute at 200 μg/mL in PBS
Function
The ED50 was found to be <0.5ng/ml using dose dependent proliferation of human pancreatic cells.
Molecular Weight
18.4
Shipping Conditions
Ambient Temperature
Storage Conditions
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Appearance
Lyophilized Powder
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS

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