Recombinant Human IL31

• Description :

  IL-31 is a recently discovered helical cytokine, belonging to the gp130/IL-6 cytokine family. The receptors for IL-6 family are type I receptors, and they share a number of common structural motifs, such as the cytokine-binding domain with two pairs of conserved cysteine residues and a WSXWS sequence motif in the extracellular domain. IL-31 is expressed preferentially by activated Th2 CD4+ T cells, signaling through a heterodimeric receptor complex composed of IL-31RA and OSMR. Recent studies in both humans and mice have suggested a link between IL-31/IL-31R expression and skin inflammation although the functional significance of endogenous IL-31/IL-31R interactions in influencing innate and adaptive immune responses remains unknown.

• CAS Number :

  9000-83-3

• Gene Name :

  IL31

• Gene Aliases :

  IL-31
  Recombinant Human Interleukin-31 (IL31)

• Gene ID :

  386653

• Accession Number :

  Q6EBC2

• Organism :

  Human

• Source :

  E. coli

• Concentration :

  <1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity :

  >95% as determined by SDS-PAGE

• Solubility :

  A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

• Function :

  The ED(50) was determined by the ability to induce STAT3 activation in U87 MG cells, and was determined to be not less than 7.0 ng/mL.

• Molecular Weight :

  18

• Shipping Conditions :

  Ambient Temperature

• Storage Conditions :

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance :

  Lyophilized Powder

• Formulation :

  Recombinant Interleukin-31 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.