CRT0066101

CAT: 0804-HY-15698-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-15698-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CRT0066101 is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively[1]. CRT0066101 is also a potent PIM2 inhibitor with an IC50 of ~135.7 nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS -induced lung injury models, and has anticancer effects[1][2][3].

CAS Number

956123-34-5

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Apoptosis; Pim; PKD

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/crt0066101.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@H](CC)CNC1=NC(C2=C(O)C=CC(C3=CN(C)N=C3)=C2)=NC=C1

Molecular Formula

C18H22N6O

Molecular Weight

338.41

Precautions

H302, H312, H332

References & Citations

[1]Harikumar KB, et al. A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther. 2010 May;9 (5) :1136-46.|[2]Xi Chen, et al. Identification and assessment of new PIM2 inhibitors for treating hematologic cancers: A combined approach of energy-based virtual screening and machine learning evaluation. Arch Pharm (Weinheim) . 2024 Jan 23:e2300516.|[3]Cui B, et al., Small molecule inhibitor CRT0066101 inhibits cytokine storm syndrome in a mouse model of lung injury. Int Immunopharmacol. 2023 Jul;120:110240.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

PIM2; PKD1; PKD2; PKD3

Alternative Products

Catalog	Name
MBS3602931-01	CRT0066101
S8366-1g	CRT0066101 dihydrochloride
T84405-01	CRT0066101 hydrochloride
531753	CRT0066101 HCl

CRT0066101

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