Anti-VEGF (Vascular Endothelial Growth Factor)(VG1), CF740 conjugate
CAT:
37-BNC741686-100
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-VEGF (Vascular Endothelial Growth Factor)(VG1), CF740 conjugate
- Description: This MAb recognizes proteins of 19-22 kDa (reducing) and 38 kDa-44 kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF). It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet-derived growth factor (PDGF). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: MVCD1; Vascular Endothelial Growth Factor A (VEGF-A); Vascular Permeability Factor (VPF); VEGFA
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: VEGFA
- Gene ID: 7422
- NCBI Gene ID: 73793
- UniProt: P15692
- Cellular Locus: Plasma membrane|Secreted (extracellular)
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Human VEGF189 recombinant protein
- Target Antigen: VEGF
- Clonality: Monoclonal
- Isotype: IgG1 κ
- Clone: VG1
- Conjugation: CF740
- Source: Animal
- Applications: IHC, FFPE (verified)
- Validated Applications: IHC, FFPE
- Positive Control: Tumor cells in astrocytomas, breast or ovarian carcinomas.
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% rBSA, 0.05% azide
- Molecular Weight: 19-22 kDa (reducing) and 38 kDa-44 kDa (non-reducing)
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years