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CW0134

CAT: 0804-HY-161391Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161391Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CW0134 (Compound 12) is a modulator for exportin1 (XPO1), which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1].
CAS Number
1076235-18-1
UNSPSC
12352005
Target
CRM1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cw0134.html
Solubility
10 mM in DMSO
Smiles
ClC1=NC(NN2C(C=C(C)C2=O)=O)=CC=C1C(F)(F)F
Molecular Formula
C11H7ClF3N3O2
Molecular Weight
305.64
References & Citations
[1]Chen YF, et al., Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation. Nat Chem Biol. 2024 Mar 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T86111-01CW0134

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