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CW0134

CAT: 0013-GTR19235533-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19235533-03Size:100 mg
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Description
CW0134 (Compound 12) is an exportin 1 (XPO1) modulator that interferes with chromatin association, leading to the inhibition of NFAT transcription factors and suppression of T cell activation. This small molecule is a valuable research tool for studying immune regulation and nuclear export in both cellular and animal models of inflammation and autoimmunity.
CAS Number
1076235-18-1
Field of Research
Pharmacology & Drug Discovery
Smiles
N (N1C (=O) C (C) =CC1=O) C=2N=C (Cl) C (C (F) (F) F) =CC2
Molecular Formula
C11H7ClF3N3O2
Molecular Weight
305.64
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-[[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-methylpyrrole-2,5-dione
CAS Number1076235-18-1
PubChem CID58230264
IUPAC Name1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-methylpyrrole-2,5-dione
Molecular FormulaC11H7ClF3N3O2
Molecular Weight305.64
XLogP2.8
Topological Polar Surface Area62.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity466
SMILES
CC1=CC(=O)N(C1=O)NC2=NC(=C(C=C2)C(F)(F)F)Cl
InChI
InChI=1S/C11H7ClF3N3O2/c1-5-4-8(19)18(10(5)20)17-7-3-2-6(9(12)16-7)11(13,14)15/h2-4H,1H3,(H,16,17)
InChIKey
AWLZJKYMAYUHJU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-[[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-methylpyrrole-2,5-dione
CAS: 1076235-18-1
CID: 58230264
Formula: C11H7ClF3N3O2
MW: 305.64
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight305.64
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass305.0178887
Monoisotopic Mass305.0178887
Topological Polar Surface Area62.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T86111-01CW0134

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