YS-370

• UNSPSC Description:

  YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity[1].

• Target Antigen:

  P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ys-370.html

• Purity:

  98.50

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 80°C)

• Smiles:

  COC1=CC2=NC=NC(C3=C(C4=CC=CC=C4)N(CC5=CC=CC=C5Br)C6=C3C=CC=C6)=C2C=C1OCCCN7CCOCC7

• Molecular Weight:

  663.60

• References & Citations:

  [1]Yuan S, et al. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021;64(19):14895-14911.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2470908-79-1