Ramelteon metabolite M-II-d3
CAT:
804-HY-103005S-01
Size:
1 mg
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Ramelteon metabolite M-II-d3
- CAS Number: 1246812-22-5
- UNSPSC Description: Ramelteon metabolite M-II-d3 is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].
- Target Antigen: Drug Metabolite; Melatonin Receptor
- Type: Isotope-Labeled Compounds
- Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
- Field of Research: Neurological Disease; Endocrinology
- Purity: 99.0
- Solubility: 10 mM in DMSO
- Smiles: [2H]C([2H])([2H])C(O)C(NCC[C@H]1C2=C(CC1)C=CC3=C2CCO3)=O
- Molecular Weight: 278.36
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Nishiyama K, et al. Pharmacological characterization of M-II, the major human metabolite of ramelteon. Pharmacology. 2014;93(3-4):197-201.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported