Mirdametinib (GMP)
CAT:
804-HY-10254G-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Mirdametinib (GMP)
- CAS Number: 391210-10-9
- UNSPSC Description: Mirdametinib (PD0325901) (GMP) is Mirdametinib (HY-10254) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Mirdametinib is an orally active, selective and non-ATP-competitive MEK inhibitor[1][2][3].
- Target Antigen: MEK
- Type: GMP Small Molecules
- Related Pathways: MAPK/ERK Pathway
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/mirdametinib-gmp.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2F)F)NOC[C@H](O)CO
- Molecular Weight: 482.19
- References & Citations: [1]Avolio E, et al. Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart. J Clin Invest. 2022 May 16;132(10):e152308.|[2]Suo N, et al. Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia. 2019 Jul;67(7):1320-1332.|[3]Ai Z, et al. Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901. Stem Cells Int. 2016;2016:1792573.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 2