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Floxuridine (Standard)

CAT: 0804-HY-B0097R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0097R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Floxuridine (Standard) is the analytical standard of Floxuridine. This product is intended for research and analytical applications. Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly (ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis[1][2]. Floxuridine has antiviral effects against HSV and CMV[3].
CAS Number
50-91-9
Product Name Alternative
5-Fluorouracil 2'-deoxyriboside (Standard)
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H341, H360
Target
Apoptosis; Bacterial; CMV; DNA/RNA Synthesis; HSV; Nucleoside Antimetabolite/Analog; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/floxuridine-standard.html
Purity
99.95
Smiles
OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(F)=C2)=O)=O)O1
Molecular Formula
C9H11FN2O5
Molecular Weight
246.19
Precautions
H301, H315, H319, H341, H360
References & Citations
[1]Huehls AM, et al. Poly (ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.Cancer Res. 2011 Jul 15;71 (14) :4944-54.|[2]Yeo WS, et al. The FDA-approved anti-cancer drugs, streptozotocin and floxuridine, reduce the virulence of Staphylococcus aureus.Sci Rep. 2018 Feb 6;8 (1) :2521.|[3]Langman J, et al. Floxuridine and its influence on postnatal cerebellar development. Pediatr Res. 1972 Oct;6 (10) :758-64.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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