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Floxuridine

CAT: 0804-HY-B0097-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0097-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly (ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis[1][2]. Floxuridine has antiviral effects against HSV and CMV[3].
CAS Number
50-91-9
Product Name Alternative
5-Fluorouracil 2'-deoxyriboside
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Bacterial; CMV; DNA/RNA Synthesis; HSV; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/floxuridine.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(F)=C2)=O)=O)O1
Molecular Formula
C9H11FN2O5
Molecular Weight
246.19
Precautions
H301
References & Citations
[1]Huehls AM, et al. Poly (ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.Cancer Res. 2011 Jul 15;71 (14) :4944-54.|[2]Yeo WS, et al. The FDA-approved anti-cancer drugs, streptozotocin and floxuridine, reduce the virulence of Staphylococcus aureus.Sci Rep. 2018 Feb 6;8 (1) :2521.|[3]Langman J, et al. Floxuridine and its influence on postnatal cerebellar development. Pediatr Res. 1972 Oct;6 (10) :758-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HSV

Alternative Products

CatalogName
A2402-100Floxuridine
A10392-25Floxuridine 25mg
S1299-01Floxuridine (FUDR)
A10392-500Floxuridine 500mg
A10392-50Floxuridine 50mg

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