Products for Research Use Only
RegisterLogin

Nicorandil-d4

CAT: 0804-HY-B0341S-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0341S-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Nicorandil-d4 (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP) . Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].
CAS Number
1132681-23-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.81
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=[N+]([O-])OCCNC(C1=C([2H])N=C([2H])C([2H])=C1[2H])=O
Molecular Formula
C8H5D4N3O4
Molecular Weight
215.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35 (6) : p. 919-25.|[3]Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275 (28) : p. 21722-9.|[4]Mitsuhiko Yamada, et al. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 2004 May;65 (5) :1198-207.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B0341-01Nicorandil
HY-B0341R-01Nicorandil (Standard)
HY-W740628-01Nicorandil pyridine oxide
HY-151912S-01Picolinafen-d4 (4-Fluorophenyl-d4)
HY-132468SKeto Pioglitazone-d4 (M-III-d4)
HY-151892SGlimepiride-d4 (phenylethyl-α, α, β, β-d4) (cis/trans)
HY-151910S(±) -Fluoxetine-d4 Oxalate (trifluoromethylphen-d4-oxy)
HY-W654154Dexmedetomidine-d4 L-tartrate (-d4-major)
HY-113313S2Aldosterone-d4
HY-10582S3Flurbiprofen-d4

Alternative Products

CatalogName
CS-O-11953Nicorandil-d4
4386436-Hydroxy Nicorandil-d4
B2197-5.1Nicorandil

Popular Products