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Nicorandil

CAT: 0804-HY-B0341-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0341-01Size:100 mg
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Description
Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP) . Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].
CAS Number
65141-46-0
Product Name Alternative
SG-75
UNSPSC
12352005
Hazard Statement
H302, H318
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Nicorandil.html
Purity
98.20
Solubility
DMSO : 100 mg/mL|H2O : ≥ 20 mg/mL
Smiles
O=C(C1=CC=CN=C1)NCCO[N+]([O-])=O
Molecular Formula
C8H9N3O4
Molecular Weight
211.17
Precautions
H302, H318
References & Citations
[1]Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35 (6) : p. 919-25.|[2]Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275 (28) : p. 21722-9.|[3]Mitsuhiko Yamada, et al. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 2004 May;65 (5) :1198-207.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
B2197-5.1Nicorandil

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