Demethylzeylasteral (Standard)

• Description :

  Demethylzeylasteral (Standard) is the analytical standard of Demethylzeylasteral. This product is intended for research and analytical applications. Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation [1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Estrogen Receptor/ERR; FAK; NF-κB; Reference Standards; TGF-beta/Smad

• Type :

  Reference Standards

• Related Pathways :

  Apoptosis; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/demethylzeylasteral-standard.html

• Purity :

  99.90

• Smiles :

  C[C@](C1=CC2=O)(CC[C@]3(C)[C@@]4([H])C[C@@](C(O)=O)(C)CC3)[C@]4(CC[C@]1(C5=C2C(C=O)=C(O)C(O)=C5)C)C

• Molecular Formula :

  C29H36O6

• Molecular Weight :

  480.59

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhang K, et al. Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis. Cell Death Dis. 2018 Oct 10;9 (10) :1035. |[2]Li L, et al. Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways. Naunyn Schmiedebergs Arch Pharmacol. 2019 May;392 (5) :593-603. |[3]Zhao Y, et al. Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells. Cell Death Dis. 2017 Oct 26;8 (10) :e3133. |[4]Wang Q, et al. Demethylzeylasteral ameliorates inflammation in a rat model of unilateral ureteral obstruction through inhibiting activation of the NF‑κB pathway. Mol Med Rep. 2017 Jul;16 (1) :373-379. |[5]Huang Y, et al. Experimental study of the anti-atherosclerotic effect of demethylzeylasteral. Exp Ther Med. 2017 Jun;13 (6) :2787-2792.|[6]Chen K, et al. Demethylzeylasteral attenuates hepatic stellate cell activation and liver fibrosis by inhibiting AGAP2 mediated signaling. Phytomedicine. 2022 Oct;105:154349.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, sealed storage, away from light and moisture

• Scientific Category :

  Reference Standards

• CAS Number :

  [107316-88-1]