RegisterLogin

Demethylzeylasteral

CAT: 0804-HY-N0587-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0587-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation [1][2].
CAS Number
[107316-88-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Estrogen Receptor/ERR; FAK; NF-κB; TGF-beta/Smad
Type
Natural Products
Related Pathways
Apoptosis; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/demethylzeylasteral.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
C[C@](C1=CC2=O)(CC[C@]3(C)[C@@]4([H])C[C@@](C(O)=O)(C)CC3)[C@]4(CC[C@]1(C5=C2C(C=O)=C(O)C(O)=C5)C)C
Molecular Formula
C29H36O6
Molecular Weight
480.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang K, et al. Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis. Cell Death Dis. 2018 Oct 10;9 (10) :1035. |[2]Li L, et al. Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways. Naunyn Schmiedebergs Arch Pharmacol. 2019 May;392 (5) :593-603. |[3]Zhao Y, et al. Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells. Cell Death Dis. 2017 Oct 26;8 (10) :e3133. |[4]Wang Q, et al. Demethylzeylasteral ameliorates inflammation in a rat model of unilateral ureteral obstruction through inhibiting activation of the NF‑κB pathway. Mol Med Rep. 2017 Jul;16 (1) :373-379. |[5]Huang Y, et al. Experimental study of the anti-atherosclerotic effect of demethylzeylasteral. Exp Ther Med. 2017 Jun;13 (6) :2787-2792.|[6]Chen K, et al. Demethylzeylasteral attenuates hepatic stellate cell activation and liver fibrosis by inhibiting AGAP2 mediated signaling. Phytomedicine. 2022 Oct;105:154349.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName

Alternative Products

CatalogName
MBS3607789-01Demethylzeylasteral
A14745-5Demethylzeylasteral 5mg
A14745-50Demethylzeylasteral 50mg
A14745-10Demethylzeylasteral 10mg
A14745-25Demethylzeylasteral 25mg
A14745-100Demethylzeylasteral 100mg
C17259Demethylzeylasteral (T-96)
A14745-10mM-DDemethylzeylasteral 10mM * 1mL in DMSO

Popular Products